Late XV century - Glusk was mentioned for the first time as Glusk Dombrovitsky, a private possession of the Dukes Golshanskies (magnate family of Great Lithuanian Princedom). The castle was constructed there on the bank of Ptich river.
1506-1791 - Glusk Dombrovitsky was a shtetle in Novogrudok District of Novogrudok Province.
1508 - Glusk Dombrovitsky was the place where rebels, led by Duke Mikhail Glinsky, talk with Rech Pospolitaya and Muscovy Russia authorities about the former exodus to Muscovy Russia.
1525 - Polish King and Great Prince Sighizmund I Old awarded Yury Golshansky with the privilege to hold regular fairs in Glusk Dombrovitsky. Soon Jewish population appeared.
1558 - Duke Semyon Golshansky, who was the last male representative of that family, died and his vast estates were inherited by his 5 daughters. 2 of them, particularly Sofia and Yelena, had got Glusk castle and all lands and settlements around.
Early 1560s - Sofia Golshanskaya married Alexander Polubinsky and Glusk shtetle became a possession of Polubinsky noble family.
1560s - Vilno high official Yeronim Khodkevich married somebody from Polubinsky family, who had got Glusk from Sofia Golshanskaya as her dowry.
1568 - Yan Khodkevich was awarded the title of Count of Glusk, Shklov, Bykhov and Mysh, so Glusk became a center of Glusk County.
End XVI century - as a result of intermariages Glusk became a mutual possession of Polubinsky and Chartoryzhsky (Polish magnates) family. Such mutual ruling called for disputes and even armed conflicts.
1605-1618 - during the war between Rech Pospolitaya and Muscovy Russia Glusk inhabitants often fought against Rech Pospolitaya noble (shlyakhta) bands, which passed Glusk on the way to Moscow and tried to rob it.
1616 - most major battle between Glusk inhabitants and noble formation. Glusk won it and captured that formation baggage tranport. Shlyakhta robbed and burned some villages around in revenge.
1628 - to stop the discussion of the followers of Brest Church Union and Roman Catholics about the superiority in Glusk County that time Glusk owner Konstancy Polubinsky founded a Roman Catholic church in Glusk and two Roman Catholic chapels in close villages.
1662 - chief councillor of Volkovysk Province Alexander Polubinsky founded in Glusk splendid Roman Catholic church and the Cloister of St. Bernardus in stone.
1775 - Glusk was burned to the ground. After it the Supreme Warsaw Sejm (parliament) liberated Glusk from all taxes for next 10 years.
1793 - Glusk became a shtetle in Russian Empire.
1801-1917 - a shtetle in Bobruisk District of Minsk Province.
1818 - local believers built Orthodox church of Resurrection in Glusk.
1832 - the Cloister of St. Bernardus was closed and liquidated.
| Date | Jews | Non-Jews | Comments | % Total Pop. |
| 1st half of XVI century | Jewish population appeared | |||
| 1620 | 3000 | No info | Both sexes | No info |
| 1847 | 3148 | No info | In the entire kahal | No info |
| 1864 | 3000 | Total population | No info | |
| 1880 | over 5000 | Total population | No info | |
| 1897 | 3801 | 2180 | Both sexes | 59.1% |
| 1909 | 6680 | Total population | No info | |
In the end XIX - beg. XX century in Glusk there were:
Since the privilege of 1525 Glusk began to develop as a local trade center.
The wars and fires, took place in the the second half of the XVII-XVIII century caused economic and general decay of the Town. During Russian principality vodka trade was under state hard control and became less popular among Jewish businessmen. But Russian authorities did a lot to develop the region because of military and fiscal reasons mostly. First of all, old communications were reconstructed there:
In XIX, because of development of the All-Russian Market, new types of communications appeared in the area in 1873. Construction of the railroad provoked new increase of the development of the region. But it did not rapidly effect to development of Glusk, because the closest railway station was 47 km afar from the Shtetle in Bobruisk. Timber and fabrics stayed the most popular goods among local Jews.
By 1882 there were over 500 wooden houses in Glusk, but the only one stone building was the old closed cloister, built in 1662.
By 1900 there were 3 leather factories in Glusk.
Here is the list of major business and trade enterprises of Glusk and the Subdistrict for 1902:
| Name of owner | Type of business | Religion |
| DEMIKHOVSKAYA Leya daughter of Dovid | Fabrics trade store | Jewish |
| FAYNSHTEYN Slava daughter of Ghirsh | Fabrics trade store | Jewish |
| GELFAND Mikhel son of David | Timber trade | Jewish |
| GOLANT Yankel & sHEYNYUK Aron | Petroleum store | Jewish |
| GORELIKs Zelik & Kagan sons of Gherman | Timber trade | Jewish |
| IMYANITOV Ayzik son of Movsha | Fabrics trade store | Jewish |
| KAGANOVICH Nokhim son of Shevel | Fabrics trade store | Jewish |
| LIFSHITS Leyzer son of Neukh | Grocery store | Jewish |
| LIVSHITS Meylakh son of David | Fabrics trade store | Jewish |
| MARGOLIN Khaya daughter of David | Fabrics trade store | Jewish |
| MASHINSKY Vlad son of Yulian | Pharmacy | Roman Catholic |
| MAYZEL Leyba son of Ghirsh | Fabrics trade store | Jewish |
| MAZE Khaym son of Aron | Flour mill | Jewish |
| RAPOPORT Yankel son of Elya | Grocery store | Jewish |
| RIVIN Yankel son of Movsha | Timber trade | Jewish |
| RYKLin Rokhlya daughter of Khaym | Pharmaceutical store | Jewish |
In 1909 in Glusk there were 870 houses.